Three points, goal difference, and progression in the competition are at stake for both clubs.
A win can secure group leadership or a safer path to the knockout rounds; a draw keeps both alive but complicates tiebreakers and home/away calculus for later fixtures.
Mikel Arteta and Diego Simeone pick the tactics and personnel that will decide the match.
Key players include Arsenal's Bukayo Saka and Gabriel Martinelli, and Atlético's Rodrigo De Paul and Álvaro Morata. The managers' substitutions and in-game adjustments are decisive.
Recent form, injuries, and suspensions will shift probabilities before kickoff.
Set-piece efficiency, pressing intensity, goalkeeper form, and control of wide areas are the technical levers that determine scoring chances and defensive solidity.
Lineups announced about an hour before kickoff reveal whether either team rests starters or tweaks formation.
Track pregame injury news, early expected-goals flow, halftime tactical changes, and any red cards or penalties that abruptly alter momentum.